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Search Results for " m. tuberculosis "

20

Compounds

Cat No. Product Name Synonyms Targets
T38359 Dup-721 Antibacterial
DuP-721 is a broad spectrum and orally active antibacterial agent. DuP-721 inhibits a variety of clinically susceptible and resistant bacteria, especially M. tuberculosis.
T1426 Pyrazinamide Pyrazinoic acid amide,Pyrazinecarboxamide Antibacterial , Antibiotic , Autophagy , Fatty Acid Synthase
Pyrazinamide (Pyrazinecarboxamide), an antimycobacterial, is utilized therapeutically as an antitubercular agent, which is a synthetic pyrazinoic acid amide derivative.
T8411 C-215 Others
C-215 is a novel inhibitor of mycobacterial membrane protein large 3 (MmpL3).
T16339 Norverapamil hydrochloride (±)-Norverapamil hydrochloride,D591 hydrochloride Calcium Channel , P-gp , Drug Metabolite
Norverapamil hydrochloride (D591 hydrochloride) ((±)-Norverapamil hydrochloride) is an N-demethylated metabolite of Verapamil and it is an L-type calcium channel blocker and a P-glycoprotein (P-gp) function inhibitor.
T25817 Mitonafide NSC-300288,NSC300288,NSC 300288 Antibacterial
Mitonafide (NSC-300288) suppresses the activity of M. tuberculosis NAD+ dependent DNA ligase A. Mitonafide is a DNA intercalating agent.
T9830 GSK2556286 GSK286 Antibacterial
GSK2556286 (GSK286) is an orally active inhibitor of Mycobacterium tuberculosis (M. tuberculosis).GSK2556286 inhibits the growth of human macrophages with an IC50 value of 0.07 μM.GSK2556286 is effective against both mul...
T5400 Q203 IAP6,Telacebec Antibacterial , Antibiotic
Q203 (Telacebec) is a novel potent anti-tuberculosis agent targeting cytochrome b subunit qcrB and inhibits M. tuberculosis H37Rv (MIC50: 2.7 nM).
T5997 TBAJ-587 Antibacterial , Antibiotic
TBAJ-587 is a potent anti-tuberculosis agent. TBAJ-587 inhibits M.tb strain H37Rv growth with MIC90s of 0.006 and <0.02 µg/mL in MABA and LORA assay, respectively. BAJ-587 has more potent activity against M. tuberculosis...
T7312 AX20017 Others , Antibacterial
AX20017 is a small-molecule protein kinase G (PknG) inhibitor(IC50 : 0.39 μM). It acts by blocking the proliferation of M. tuberculosis.
T7342 BM212 Antibacterial
BM212 is an antimycobacterial compound.It inhibits the growth of laboratory and clinical isolate M. tuberculosis strains.
T0020 Sodium 4-aminosalicylate dihydrate Sodium 4-Aminosalicylate,4-Amino-salicylic acid sodium salt Free radical scavengers , NF-κB , Antibacterial , Antibiotic
Sodium 4-aminosalicylate dihydrate (4-Amino-salicylic acid sodium salt) is the sodium salt form of aminosalicylic acid, an analog of para-aminobenzoic acid (PABA) with antitubercular activity. Sodium 4-aminosalicylate di...
TQ0184 Chebulinic acid ATPase , Proton pump , DNA/RNA Synthesis , Antibacterial , TGF-beta/Smad
Chebulinic acid is a potent inhibitor of M. tuberculosis DNA gyrase. It also can inhibit SMAD-3 phosphorylation and H+ K+-ATPase activity.
T4964 Steviolbioside CCRIS-6025 Others
Steviolbioside (CCRIS-6025) is a natural sweetener, it presents notable inhibition on human hepatocarcinoma cell Hep3B, human breast cancer cell MDA-MB-231 and human pancreatic cancer cell BxPC-3, thus, steviolbioside(CC...
T27482 GSK572A Others
GSK572A is a novel and potent potent inhibitor of EchA6, which can be used to treat tuberculosis.
T4531 GSK2200150A Antibacterial
GSK2200150A is an anti-tuberculosis (TB) agent identified by high-throughput screening (HTS) campaign.
T60446 LCS3 Apoptosis , Glutathione reductase
LCS3 is a reversible and non-competitive synergistic inhibitor of glutathione disulfide reductase (GSR) and thioredoxin reductase 1 (TXNRD1) with IC50s of 3.3 μM and 3.8 μM, respectively. LCS3 has antitumour activity, in...
T10563 BM635 Others
BM635 is an MmpL3 inhibitor with outstanding anti-mycobacterial activity (MIC50: 0.12 μM against M. tuberculosis H37Rv).
T10563L2 BM635 mesylate (1493762-74-5 free base) BM635 mesylate Others
BM635 mesylate is an MmpL3 inhibitor with outstanding anti-mycobacterial activity (MIC50: 0.12 μM against M. tuberculosis H37Rv).
T10563L BM635 hydrochloride (1493762-74-5 free base) BM635 hydrochloride Others
BM635 hydrochloride is an MmpL3 inhibitor with outstanding anti-mycobacterial activity (MIC50: 0.12 μM against M. tuberculosis H37Rv).
T39693 Polyketide synthase 13-IN-3
Polyketide synthase 13-IN-3 (compound 41) is a potent inhibitor of polyketide synthase 13, demonstrating a minimum inhibitory concentration (MIC) range of 0.0625-0.125 μg/mL against the M. tuberculosis strain H37Rv.
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TargetMol